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Transcript
I put together the PowerPoint presentation that has been converted into this series of mini videos for YouTube altogether there are nine Parts this is part 1 because of the length of the opening animation and the 10 minute YouTube limit I cannot start with the usual set of introductory remarks but rather than abandon them they have been moved into the opening dialogue of subsequent videos so if you have questions about why am I telling you this story why isn't this information on Primetime TV News why is this presentation so technical please be patient will get to them in the ninth video contact information will be provided for how to get in touch with me how do I arrange for consulting services with scientific medical professionals who understand the themes of this presentation and where to find additional resources let's start with the take-home message you can prevent and reverse Alzheimer's disease this presentation will show you the central metabolic failure in the Alzheimer's disease process and how to go about fixing it it will also present the possible complicating factors that may be aggravating it but he will not tell you everything that you should or might do a particular case of Alzheimer's disease may have other complications at Play from a deficiency of B12 or B3 or toxicity from lead or trans fat or inflammatory activation from toenail fungus or food allergy to wheat this is not a strict recipe for Alzheimer's reversal you will have to figure out which parts of the program are the highest priorities for your particular case but one thing is clear the earlier you start the better the results this is because the metabolic malfunctions in the earliest stages of Alzheimer's disease are known to be largely reversible but the cell damage to neurons and dendrites or the outright cell death known as apoptosis that are believed to accumulate over time are mostly not reversible let me paint a picture for you of Alzheimer's disease step by step starting with a dashed line which is slanted to show that the Universe and our environment are not Level Playing Fields and that we need to strive to stay alive specifically here I want to convey redox potential redox is a fancy name for the balance between reduction the gaining of electrons and oxidation the losing of electrons reduction oxidation redox for short redox is important because our bodies need lots of electrons to be alive but are oxygen nitrogen atmosphere is very poor in electrons so we must struggle to get electrons if we lose that struggle we slide down the dash line into death the star of our movie is glutathione which is abbreviated gsh the G stands for glutathione and the sh stands for the self Hydro Group which is its active site glutathione is rich in electrons which are carried on the sofa Hydro group in her wisdom Mother Nature has provided us with lots of glutathione so that the redox balance always stays tip to the reduce side in opposition to the slant of the line which is tipped towards oxidation when some oxidative stress comes our way the glutathione offers up its electrons as a sacrifice so that other more important body structures are not damaged by having their precious electrons stolen bsh converts to us and we end up with gssg which is oxidized glutathione the oxidized glutathione has now done its job and is used up but it is not forgotten Mother Nature has also provided a way to give back the electronic glutathione to restore it to its reduce state this reduction of oxidized glutathione back into reduced glutathione is driven by the energy systems of the body this recycling of glutathione allows each glutathione a molecule used hundreds and thousands of times before it may become irreversibly damaged but glutathione also moonlights as a Mercury to talk safire by binding to Mercury which has the symbol HG glutathione convert mercury into a bound form gshg which has dramatically less toxicity this shifts the balance of the Mercury closer to the fulcrum point on the teeter-totter which keeps it from tipping the wrong way next to the Teeter Totter are the Alzheimer's disease enzyme systems that are sensitive to Mercury these enzymes have self Hydro groups in their active sites so glutathione must bind all the Mercury to prevent the Mercury from binding to the enzymes when the Energy System falters glutathione recycling becomes impaired this decreases the amount of glutathione and allows Mercury to escape finding free Mercury increases this tips the balance and knocks over the first Domino the enzyme creatine kinase which would otherwise provide the cell with emergency backup energy Reserves then the phosphorylation Domino Falls this phosphorylation cycle would otherwise regulate the long-term stability of brain metabolism and keep the brains microstructure adjusted properly continued Mercury influence then knocks over the microtubule Domino which would otherwise transport material down the long thin axons and dendrites of the brain and finally after extended weeks and months of ongoing Mercury mediated pathology beta amyloid plaques form which clogs the brain with garbage this is the state at which Alzheimer's disease is finally recognizable and it's full-blown medical context and where it might be identified by standard tests like brain-imaging or autopsy micrographs what is the strategy for reversal restore cellular energy mechanisms increase energy to recycle more glutathione find Toulouse Mercury decrease Unbound Mercury and tip the scale back to a reduce State then natural healing mechanisms can replace inhibited enzymes reactivate the phosphorylation cycle reassemble microtubules and digest beta-amyloid protein although energy restoration is likely to be the biggest influence there are many other adjunct therapies to assist with the process like reducing total body Mercury burden increasing the amount of glutathione that the body makes reducing secondary stresses to the glutathione system information for example or correcting nutrient deficiencies that impair metabolic efficiency now it's time to switch back to a verbal summary
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Transcript
We just finished the following Domino's illustration and now revert to a verbal summary of the Alzheimer's Cascade then we will start a deeper exploration of the brain's metabolic uniquenesses and its special requirement for biological energy Alzheimer's disease is caused by a loss of glutathione cycling one of glutathione trolls is to detoxify Mercury if glutathione is always greater than the Mercury burden than the toxicity of mercury is kept low glutathione is also an antioxidant which defends the cells against free radicals and oxidation oxidized glutathione does neither oxidation of glutathione causes release of bound Mercury release mercury poison self hydril enzymes Zohydro enzymes are vital parts of several critical brain systems including microtubule maintenance the phosphorylation cycle and the energy backup system sulfhydryl enzyme failure is a defining characteristic of Alzheimer's disease and glutathione restoration reverses Alzheimer's disease why is the brain special there are several things that we can point to as highlights to illustrate this point some aspects of metabolism are unique to the brain the phosphorylation cycle in which brain enzymes are phosphorylated and dephosphorylated every 90 seconds is a good example of this brain neurons also have a unique shape involving very long and thin extensions or branches called axons and dendrites which form the neural networks necessary for cognitive function this requires a unique Reliance upon the transport system called microtubules that move materials from the center nucleus of the cell down the axons and dendrites to the periphery of the neurons where the receptors for neurotransmitters are located they also move materials back to the nucleus these microtubules if they were scaled to the size of two lane Highway would stretch from San Diego to Maine will come back to microtubules later the brain also has unique functions not only are the electrical signals of sensory systems and motor control systems process by the brain but many of the hormones of the body are sensed by the hypothalamus and regulated by the pituitary glands in the brain these are intimately involved in health aging and lifespan the brain is also isolated behind the blood-brain barrier which selectively passes and rejects certain chemicals to make the brain work properly these factors can make the brain less sensitive to certain adverse influences in the world like alkaloid poisoning from plants that are trying to keep us from eating them or infections that are fought by the immune system on the body side of the blood-brain barrier or insulin resistance which affects the glue for glucose Transporters of the body and not the glute one Transporters that are favored by the brain these brain uniquenesses can also make the brain more sensitive to other influences like excessive coagulation that impairs brain perfusion more than body workin's carbon monoxide poisoning which also selectively damage is consciousness more than body organs heavy metal especially Mercury which damaged brain development to a much greater degree and hypothyroidism which directly undermines energy that the brain disproportionately consumes the sensitivities of the brain all cause impairment of energy utilization by the brain energy is the key we will come back to the central point many times in the following presentation the bottom line is that the special sensitivities and insensitivities of the brain mean that body pathologies are not necessarily associated with brain pathologies there are many demented people who are otherwise quite robust and there are conditions of extreme physical disability in which mental acuity is minimally affected even within the brain sensitivities can be selective in Parkinson's disease the parts of the brain dealing with more and motivational tone are selectively affected cognitive function may not be noticeably impaired at all energy how does it work biological energy is what maintains the structure and function of the body systems against the forces of chaos chaos is not the secret spy organization that Maxwell Smart thought but rather entropy the principle of disorder defined by the second law of Thermodynamics which states that closed systems always run down or that they're high-quality energy dissipates into waste Heat practical examples of entropy might be the one on clock that runs down the perfume that starts out strong and weakens as you wear it the battery in your cell phone that loses a bit of its stamina everytime you recharge it or the warmth in your house that you have to replace as it leaks out to walls and windows or your car's motor that needs to be tuned every 10000 miles and rebuilt every hundred thousand miles it is an actual law of physics that the universe is falling apart biological systems have to fight entropy to survive and energy is the tool used to fight entropy and stay alive biological systems accomplish this feat by extracting energy from their external environments and using that energy to stabilize their internal environment so order or anti-entropy within an organism is obtained at the expense of much greater disorder or entropy in the external environment in other words we are borrowing energy and paying interest on that borrowing this does not violate the second law of Thermodynamics because biological systems are open systems in essence living systems pump enter pee into the external environment in which they live if they cannot do this they die the anti-entropy currency that living systems use is ATP or adenosine triphosphate ATP is also called the energy molecule because it drives the enzyme activity needed for life there are variations on ATP called GTP CTP and creatine phosphate that can be produced from ATP and can convert back into ATP GTP and creatine phosphate have a special role in the brain reducing power is also a form of energy that is tapped just before it would otherwise be converted into ATP reducing power is used to directly regenerate the antioxidant defense system more efficiently than ATP can accomplish this also is of extreme utility to the brain it is the efficiency of energy systems that enables Advanced life-forms warm-blooded animals central nervous systems and consciousness biological Energy Systems coming to kinds the anaerobic system which is more primitive and supports only single cell life and the Aerobic System which supports multi-cell and larger life-forms the anaerobic system partially Burns glucose and generates lactic acid while the Aerobic System fully Burns glucose or fat all the way to carbon dioxide the anaerobic system generates only two ATP per glucose partially burned while the Aerobic System generates 38 ATP from each glucose fully burned to atp's is enough to support life but 38 atp's is enough to support multicellular life central nervous systems and consciousness Transcript
Here we will present a one-page map of the Alzheimer's process and the first domino in the Alzheimer's Cascade but before that give me a minute to develop one point given the popular belief that a diagnosis of Alzheimer's disease is tantamount to a death sentence a death of the self if not if the body the reversibility of Alzheimer's disease may be difficult to accept why isn't this Front Page News you might ask there are two answers to this question one flattering and one not first the researchers at the University of Kentucky and the University of Calgary who cracked the Alzheimer's code we're Dentistry scientists not Alzheimer's researchers and so the Breakthrough came through the backdoor furthermore their research implied a fundamental criticism of two of the core assumptions of the u.s. dental profession that mercury-containing Dental fillings were basically safe and it root canal procedures are basically safe second the new understanding of Alzheimer's disease favored generic therapies not high-profit drugs it did not support the billions of dollars already invested by drug companies in finding a disease management solution to the Alzheimer's problem but rather undermined it with non Prescription Solutions that can be bought at your local health food store Supermarket or neighborhood pharmacy this diagram is a flowchart for Alzheimer's disease it is provided for those of us who do better with pictures than with words please do not worry about not understanding at all and first glance or even after a once-through the presentation it has all the core elements and systems in one chart so it has to be complicated but we will talk about each section of the diagram and turn so that by the end of the presentation you should understand most of it to help Orient you the diagram is color coded with the energy system in the center and yellow like sunlight to indicate power or energy feeding it from above is the circulatory system in red the color of blood with glucose oxygen and fat dry Ketone fuels as the energy inputs delivered by Blood The Energy System output is ATP GTP and nadh where ATP and GTP are still in yellow and nadh is the most powerful reducing agent is icy blue which is a cold color to indicate antioxidant power so the cold antioxidants protect against the hot free radicals that are on automatic consequence of the energy production process the magenta to violet color tones indicate Alzheimer's Associated phenomena with the earlier stages being Vivid magenta and the latter stages being more muted Violet although most of the Alzheimer's elements are grouped on the right side they flow from the extreme left of the diagram via a magenta dashed line from where Mercury the brightest magenta is in a dynamic balance with the antioxidant glutathione glutathione is the principal antioxidant of the cell and is responsible for detoxifying Mercury both roles are fundamentally critical to health and especially critical to the function of the brain and it is the loss of glutathione dominance over Mercury that tips the balance and initiates Alzheimer's pathologies all of the remaining slides deal with some aspect of the general role of the glutathione system and the specific consequences of glutathione failure to known aspects of Alzheimer's disease we will start with Energy Systems in the center of the diagram and then Branch out to peripheral elements of the diagram a bit later mitochondria are the aerobic power plants of the cell the small inside area is magnified in the large illustration to show details of the membranes and intermembrane spaces the mitochondria is job is to produce reducing power nadh in blue and energy ATP in red mitochondria are small bean-shaped cellular organelles with a double membrane the inner membrane of which is convoluted or pleated like an accordion to maximize surface area the key energy production structures are proteins floating in the inner membrane labeled complex 1 through complex 5 these complexes form a chain which is cold blue at one end and hot red on the other end the blue and complex one accepts the fuel or reducing agent nadh also in blue and the red end complex for except the oxygen which is the oxidizing agent the power transfer system is from complex one complex 3 and complex for which pump protons or H+ across the inner membrane and complex five which converts the accumulated proton pressure call proton motive Force into ATP the key take-home concept is that nadh plays two critical roles in the energy systems first the production of ATP is completely dependent on nadh which pushes the power transfer system at the cold end of the chain to compliment oxygen pulling the power transfer system at the hot end of the chain second nadh is a source for reducing power to recycle antioxidants like glutathione and vitamin C the significance of both of these Concepts will be elaborated a bit later but first let's talk about the backup power system creatine kinase is a battery backup system for the cell it is a self Hydro enzyme meaning that it has an sh group at its active site just like glutathione does so it has the same affinity for mercury that glutathione does but there's thousands of times more glutathione around to protect the creatine kinase from Mercury inhibition creatine phosphate is the storage form for the backup energy creatine kinase converts ATP to creatine phosphate when ATP is plentiful which is shown by the blue arrows and it runs backwards to convert creatine phosphate back into ATP when ATP is scarce as shown by the white arrows this extends the cell's energy reserves from a couple of seconds too many seconds creatine kinase is known to be inhibited by Mercury and it is 95% inhibited and Alzheimer's disease this catastrophic failure of the energy backup system contributes to memory impairment cognitive dysfunction and a serious loss of physical stamina deficiencies of ATP adversely affect the activity of enzymes this has inhibiting effect on protein synthesis neurotransmitter synthesis steroid synthesis maintenance of electrical Potentials in neurons and a whole host of other health-related prophecies ATP shortages also decrease the availability of GTP and ATP cousin that assembles and maintains the tubulin infrastructure of brain neurons that facilitates material transport down neural axons and dendrites now let's move up from the yellow Energy Systems to the red circulatory system the heart and circulatory system are responsible for delivering oxygen glucose fats and Ketone fuels to the Deep tissues of the body and for removing the waste products of energy metabolism this system also includes the lungs which must adequately absorb oxygen from the air and Outkast carbon dioxide that results from energy metabolism Transcript
That the foundation for energy has been laid part four will move on to the cardiovascular system and start the discussion of the differences between the two different primary fuels glucose and fat which can either sabotage or restore energy production mechanisms but first let me take a minute to tell you how I came to be telling you this story after my grandfather develop Alzheimer's disease while I was in college enhancing cognitive function and reversing senility syndromes became a personal application for me for 30 years I have been searching for a solution to Alzheimer's disease in 1993 the chapter on Alzheimer's disease in the book smart drugs to the Next Generation written with John morgentaler and dr. Ward Dean was an early attempt to provide practical advice but it wasn't everything-but-the-kitchen-sink solution because we did not know what the metabolic mechanism of Alzheimer's disease was at that time but in the late 90s research was underway at the University of Kentucky and the University of Calgary that would end up providing the missing link to a comprehensive understanding of Alzheimer's disease culminating in 2000 and 2001 with the definitive evidence of the earliest step in the Alzheimer's disease process by 2002 for the first time we found out with the first domino in the Alzheimer's Cascade was now that we know the specific details of the metabolic process we can prevent and reverse Alzheimers disease before we could only ameliorated now we can fix it there is lots of evidence that cardiovascular problems produce both physical and cognitive disorders here are some congestive heart failure is a crisis of the heart muscle which can respond effectively to such energy based therapies as supplemental coenzyme Q10 and mitochondrial nutrient and Ketone fuels which are known to increase heart ejection fraction in rodents in just 30 minutes those people cultivating ketosis for such problems should know that IV glucose rapidly shuts down liver production of Ketone fuels and should be avoided as a medical procedure unless absolutely necessary for example when glucose Falls below 50 blood coagulate puppies can have powerful adverse effects on both physical and cognitive functions hypercoagulation involves High viscosity of the blood which impairs tissue perfusion it's like molasses in January it takes a long time to get anything done sublingual or IV Heparin vs. hypercoagulation in minutes to hours and oral nattokinase reverses hypercoagulation in hours today's if symptoms change for the better with such therapies hypercoagulation should be immediately suspected blood gas in pyramids can also be caused by such lung diseases as emphysema or COPD which are routinely diagnosed or by Blood pH dresses which are highly unlikely to be diagnosed The Binding and release of oxygen by the hemoglobin in red blood cells is driven by my new changes in PH and so pH disturbances can interfere with this process the same kind of pH sensitivity occurs with hemoglobin binding and release of carbon dioxide and pH also affects the carbon dioxide bicarbonate equilibrium which is independent of hemoglobin carbon dioxide is a mediator of vascular dilation and blood flow to the cerebral cortex deficiencies of CO2 cause decreased blood flow to the cerebral cortex without diminishing blood flow to the limbic systems and cerebellum which impairs thinking and memory but not emotion motivation and movement this is commonly noticed during fear phobias panic attacks anxiety stage fright and other forms of sympathetic activation which Drive shallow and Rapid breathing which blows off CO2 shallow rapid breathing and blowing off CO2 or a good thing when you are trying to outrun a bear but a bad thing when you are taking a test or speaking to a group hiccups and tachycardia are examples of CO2 deficiency conditions which may be more common in people with low energy metabolism and senility syndromes mechanical obstruction of the vascular system by plaque and clots can also cause disease and cognitive dysfunctions sometimes this is caused by impaired collagen maturation which can be readily reversed by Matthias Rath protocol involving vitamin C and Proline or buy more comprehensive protocol that includes glycine predigested collagen protein bioflavonoids transdermal copper and oral silica the soft tissue calcification of plaque tends to make plaque difficult to reverse which may be addressed by magnesium higher than RDA vitamin D strontium and vitamin K with or without adjunctive EDTA chelation therapy basal constriction and basal spasm or another related risk that may also derive from deficiencies of magnesium and vitamin D and also from impaired nitric oxide production nitric oxide may be the active mechanism for the cognitive enhancing effects of Ginkgo biloba with vinpocetine and arginine the key energy related inputs of the blood are glucose and Ketone fuels glucose is the primary or first used energy fuel so let's talk about it first glucose is derived from dietary carbohydrates when such foods are plentiful and from fats when carbohydrate consumption Falls below energy needs the transport of glucose from the blood into the cells is actually quite complicated but since this is intimately associated with Alzheimer's disease let's take a brief look this diagram adapted from a lead article from nutrition reviews in 2003 shows that glucose utilization the Sian blue pathway can become impaired in many ways as indicated by the red X's this state of glucose underutilization is called insulin resistance because something goes wrong with the insulin signal and green which results in an adequate mobilization of glute for glucose Transporters from the reservoir within the cell to the cell surface insulin resistance or Syndrome X or metabolic syndrome is most likely caused by overeating particularly of carbohydrate rich foods and it is a risk factor that is well connected to senility dementia and Alzheimer's disease but please note that the Ketone fuel pathway and yellow is not subjected to any of these impairments BHB or beta hydroxybutyrate is efficiently transported straight through the cell in mitochondrial membranes where it efficiently enters the Krebs cycle just below BHB is acetoacetate and archaic name for beta keto butyrate which also flows straight into the energy production pathways the opening of the keto fuel Pathways not only bypasses the energy deficits caused by insulin resistance but it is probably one of the most efficient ways to clinically decrease insulin resistance now let's switch our discussion from glucose is fuel to ketones as fuel Transcript
This is where we will talk about fat burning systems in great detail why such detail give me a minute to explain there are a lot of different kinds of people in the world who think in different ways some are practical others are dreamers something first others feel first some analyze others into it some people accept easily others are Skeptics this presentation is slanted to Skeptics it may therefore be somewhat tedious to most listeners for this I apologize but it is also for doctors your Physicians cannot afford to accept therapeutic claims at face value so this presentation must provide detail that your doctor will respect it must also provide sufficient detail that if your doctor dismisses it you will have the confidence to go elsewhere to get the medical support you need ketones fuels are produced by the mobilization and Metabolism of fat in a healthy person about 80% of the Ketone fuel produced is hydroxybutyrate in about twenty percent is keto butyrate no acetone is produced but in the unhealthy this ratio can become Disturbed and favor keto butyrate which increases the risk of acetone generation utilization ketones is impaired by lack of use of this pathway for decades keto butyrate levels can rise sufficiently to cause acetone generation acetone is not good to have around it is not if you will it is not metabolized it can participate in cross-linking reactions and it can only be gotten rid of buyout casting to the lungs which causes acetone breath there are two testing systems that can be used for assessing the presence of Ketone fuels the inexpensive urine test strips available without a prescription to your neighborhood pharmacy do not detect hydroxybutyrate but do detect keto butyrate they also react with acetone which provides a false elevation of the reading so it is a good idea to have somebody in your life who can tell you if your breath starts to smell like acetone or you can just stay away from the strongest readings by a milder program of carbohydrate restriction the Ketone fuels produced by being in ketosis have additional health benefits first for most body tissues they are preferred fuel over glucose by roughly a factor of 10 the Hartford example strongly prefers Ketone fuels in rodents suffering from congestive heart failure there is a 50% increase in heart pumping power within 30 minutes of Ketone Administration Ketone fuels appear to become increasingly favored during the developmental process and maybe the key to graceful aging there may be a close relationship between the ability of ketones to promote differentiation and prevent dedifferentiation which has potential implications to cancer therapy and may account for the therapeutic benefits of fasting in cancer therapy and lastly despite countless Decades of propaganda to the contrary the brain is capable of driving 50% of its energy needs from Ketone fuel this adjustment takes about 2 weeks getting into ketosis is relatively simple since fat burning systems are the backup power generating system and inadequacy of carbohydrate fuels is sufficient although fasting certainly induces ketosis and may be useful for short periods of time it is hardly necessary to go to such extremes there are two low-carb diets to consider the Atkins diet which is high in protein and moderate and fat and the Azran diet which is moderate in protein and high in fat due to the liabilities of excess protein the Azran diet is probably much preferred in middle-aged and elderly individuals particularly when the fat component is rich in short and medium chain triglycerides like when coconut oil is used as a dietary staple although butter and human breast milk do contain medium chain triglycerides the most concentrated sources are coconut oil and palm oil despite the government-sponsored propaganda that these are dangerous these oils are much safer than the polyunsaturated oils grown by us vegetable oil producers the only vegetable oil you should consider safe for unlimited consumption is olive oil and that does not include imported olive oils that are adulterated by non olive oils before they are important personally I use only estate-bottled olive oils from California for long-chain fats I also rely upon purified MCT oil for increasing my dietary MCT content I like the taste of butter which is only 5% MCT but by mixing butter and MCT oil 50/50 I get a butter like source of fat that taste like butter has the same MCT content is coconut oil and is spreadable straight out of the refrigerator ketosis is also facilitated by mitochondrial nutrients ketosis can be metabolically inefficient when it has not been activated for decades body fat deposits can contain toxins that can be released when fat gets mobilized and trans fats and conjugated fats from partially hydrogenated vegetable oils can sabotage the fat burning enzyme systems if your body fat is not clean it may take a while to burn out the gunk but which regular ketosis going into and out of ketosis the fat-burning mechanisms can become highly efficient as cellular utilization of ketones becomes more efficient less ketones spills into so over time you will tend to see less color on the test strips for any given degree of ketosis although most of the cells of the body are fully capable of burning fatty acids independently ketosis is characterized by the liver breaking fat down into Ketone fuels and exporting wholesale to the rest of the body through the bloodstream where they are absorbed by peripheral organs and converted into energy this metabolic detail is from Van Italy's and neufert nutrition reviews article from 2003 it is provided only for those few viewers who have an interest in such detail everybody else should immediately advance to the following discussion of the antioxidant defense system the yellow Energy System in the center of the diagram outputs nadh on the left side this couple's to nadph which is the primary pool of reducing power for biological systems this reservoir of reducing power is used to recycle antioxidants particularly vitamin C and glutathione which take the brunt of oxidative stress to the cell the glutathione antioxidant require special mention due to its dual role as a Mercury detoxicant the dynamic balance between glutathione and Mercury is the key element that regulates the earliest stages of Alzheimer's pathology there is also evidence that mercury glutathione balance is involved in autism vaccination crises and sudden infant death syndrome Transcript
This segment of the presentation begins with nadh and the antioxidant defense system nadh is the underlying foundation of the antioxidant defense system nadh carries reducing power in other words it's cold when nadh transfers its reducing power recycle One Touch of cycle to it becomes a nadie which is the oxidized form ready for collecting more energy and they nadp becomes reduced to nadph which is the initial reservoir for reducing equivalents but it doesn't stop there were cycle to touch a cycle 3 glutathione reductase uses nadph to reduce oxidized glutathione gssg back into reduced glutathione gsh the pool of reduced glutathione is the single largest reservoir of reducing equivalents in the body it is the chemical foundation of life and the key to a non Alzheimer brain other antioxidants like vitamin C and vitamin E rely upon glutathione for their recycling glutathione is the primary cellular antioxidant because it contains an sh group the sh group is its active site for both its antioxidant activity and its Mercury binding activity mercury has an extreme preference for binding to sulfur as evidence by the primary Mercury or in the Earth crust Cinnabar being Mercury sulfide because of the special Affinity of mercury and sulfur also Hydro containing enzymes are at risk for mercury poisoning Mercury is not the only element with an affinity for Sulphur lead also preferentially binds to sulfur and Lead sulfide Galena is the primary LED or although lead toxicity does not seem to be sufficient for inhibiting the soap Hydro enzymes that trigger Alzheimer's disease lead toxicity may be involved in increasing Alzheimer's risk indirectly possibly through aggravation of insulin resistance or increasing sensitivity to inflammation so it's probably a good idea to assess all toxic Metals as part of an Alzheimer's prevention reversal program including iron now that mercury toxicity is identified as the Domino tipping influence in the Alzheimer's disease Cascade let's switch our attention Downstream by following the dashed magenta line we have already covered some of the ATP impairments with the discussion of creatine kinase and its naughty 5% inhibition and Alzheimer's disease this is an example of a soft Hydro enzyme that is common to the body and brain but let's shift our attention to the other self hydril enzymes that play in even more dominant role in the brain no example is more apt than a kinase and phosphatase enzymes that regulate the brain's phosphorylation cycle kinases and phosphatases are classes of enzymes some of which have so Hydro groups at their active sites kinases add phosphate groups to other molecules like creatine kinase adds a phosphate group to creatine can AIDS is also at phosphate groups to other kinases and phosphatases which changes their activities so kinases are part of the regulatory feedback loops that adjust enzyme activity to meet metabolic needs protein kinase C is just one of the so Hydro base kinases that is inhibited by Mercury and an Alzheimer's disease protein kinase C is most highly expressed in brain tissue phosphatases work oppositely to kinases they remove phosphate groups from enzymes and like kinases remove phosphate groups from other phosphatases and kinases which can undo the activity alterations accomplished by the Kennedys because kinases can upregulate and down regulate the activities of other kinases and up and down regulate the activities of their phosphatase counterparts the kanae's phosphatase Dynamic is not linear or stable in fact the system is wired to operate in a metastable state which tips into an over phosphorylated State before the phosphatases become active enough to reverse the process the phosphatases then overdrive the system into an under phosphorylated state which eventually turns off the phosphatases and reactivate the kinases brain enzymes and brain structures that are phosphorylated or dephosphorylated by these enzymes oscillate back and forth between being over and under phosphorylated every 90 seconds this is one of the reasons why the brain which is only 3% of the body's Mass consumes roughly 20% of the body's energy this oscillation of phosphorylation probably has a fundamental role in maintaining the long-term stability of the brain although it may seem counterintuitive oscillating systems tend to have Superior long-term stability overdamped systems the ability of the female menstrual cycle to postpone a wide range of Aging effects is but one example this principle is also widely exploited in electronics to create circuits with extreme long-term stability in the brain one of the things that this oscillation accomplishes is cyclic adjustments of the cytoskeleton with Selective inhibition of protein can a sea and Other Self hydro kinases and phosphatases by Mercury the kinase phosphatase Dynamic is disrupted which has catastrophic effects on the phosphorylation of brain proteins that are essential to the cytoskeleton like kinases and phosphatases the cytoskeleton plays a much more dominant role in the brain than the body nowhere is this more true than with microtubules the component of the cytoskeleton that provides Transportation infrastructure for active transport of materials which is indispensable for neural Transportation down the exceedingly long axons and dendrites of brain cells microtubules are assembled in maintained with GTP has the energy molecule and are depolarized and disassembled by the toxic effects of Mercury Transcript
We get to the point where the Alzheimer's Cascade goes mainstream where it becomes recognizable as Alzheimer's Disease by doctors and researchers microtubules are assembled from Alpha and beta tubulin proteins using GTP as the energy source first GTP is used to assemble dimers then another GTP is used to assemble each dimer pear into multiple strands 13 of which spontaneous into each microtubule microtubules serve as a transportation that work just like a highway system where semi tractor-trailers Hall groceries from a central warehouse to local supermarkets microtubules are polarized meaning that they have Direction and always point from the nucleus of a neuron down the axons and dendrites to the nerve terminal in other words from the central warehouse to the neighborhood stores there are two kinds of semi tractor trailers the Kennison motor proteins attached to the microtubule facing forward and moves outbound material from the nucleus to the terminus the dining motor protein attaches backwards and moves other materials inward bound towards the nucleus beta tubulin contains multiple so Hydro groups two of which are immediately adjacent to the active site for GTP binding in the presence of mercury GTP binding is inhibited and microtubule assembly is prevented this Toxic effect of mercury also disassembles assemble microtubules into 2 billion pieces beta tubulin binding is known to be inhibited and Alzheimer's disease GTP binding by Beta tubulin is also known to be inhibited by root canal teeth this not well-known finding suggests that a Comprehensive Dental evaluation by a practitioner armed with a beta tubulin sensitive as he should become a high-priority part of an overall clinical evaluation for Alzheimer's disease it also suggests that people interested in prevention should either avoid root canal procedures in favor of extraction or use more sophisticated root canal procedures utilizing ozone to sterilize Dental tubules of anaerobic bacteria and calcium oxide slurries to fill Dental tubules one of the supplemental slides at the end of this presentation has additional details about one known root canal neurotoxin one last item there is test tube evidence that mercury toxicity towards microtubules is aggravated by zinc the clinical imported this finding is not clear but additional details of this finding are presented in one of the supplemental slides at the end of this presentation there are other Alzheimer's disease related phenomena that relate to Mercury toxicity that we have yet to discuss this will begin with Tau protein one of the most important of the Alzheimer's phenomena that have not yet been mentioned are neurofibrillary Tangles which are made up of microtubules Associated Tau protein these Tangles are visible under microscopes and are one of the Hallmarks signatures of a post-mortem Alzheimer's diagnosis done at autopsy the Tau protein in these Tangles has been determined to be over phosphorylated which is a midterm manifestation of Alzheimer's disease caused by earlier to stabilization of the kinase phosphatase enzyme systems that have already been mentioned one of the most well-known manifestations of Alzheimer's disease is beta amyloid plaque which is predominantly made up of beta-amyloid protein this plaque is well-known because it is highly conspicuous under microscopes a dominant feature at autopsy and was one of the first signs identified as being associated with Alzheimer's disease however beta amyloid plaque does not accumulate until later stages of Alzheimer's disease and is therefore not likely to be causal influence in the underlying pathology a far more important factor that is critically associated with Alzheimer's disease risk is inflammation however this subject will be postponed for more detailed discussion later in the presentation another risk factor that is well-known is the genetic risk from apoe although apoe genotype is probably not anywhere as important as inflammation it is hypothesized to have a direct bearing on Mercury status and is therefore intimately tied to the theme of this presentation there are three variations of the apoe gene in humans we get one apoe gene from each parent so we each carry to a Bowie jeans apoe3 is by far the most common form and roughly 90% of the population carries one copy of the apoe 3-g and roughly 60% carries to a Poe III jeans there are two less common variant a poet jeans apoe2 which is protective regarding Alzheimer's risk and apoe4 which increases risk so on the chart of all possible combinations of these jeans from your mother and father having two of the high risk jeans has the earliest onset having only one of the high-risk Gene is the next earlier onset having to medium risk jeans or one high risk in one protective Jean gives even later on set and having one protective and no high-risk Gene provides the latest age of onset having two protective jeans would presumably be even later on set but that is so rare that there is no statistical evidence to prove it yet regardless the risk is oriented diagonally across the chart the apoe genes code for a protein which is made up of a chain of amino acids when the amino acid sequences of these proteins are compared all but two of them into acids are identical the two that are different light positions 112 and 158 on the chain the protective protein has two systems at these positions the most common a poet protein has 116 and when Arginine and the high-risk protein has two argentines at these positions the amino acid cysteine contains the self Hydro group just like glutathione is it possible that these cysteine residues could bind to Mercury and decrease the brain's Mercury burden the correlation seems too perfect for this not to be the case the arrows for cysteine and the Alzheimer's risk are exactly identical now let's return to a more detailed discussion of inflammation this concludes the genetic discussion Transcript
This presentation finally we get to the huge and vitally important topic of inflammation inflammation is the core of one of the oddest puzzles of Alzheimer's disease in a disease that is positively associated with Mercury as a risk factor why does the consumption of fish which contains elevated levels of mercury actually lower Alzheimer's disease incidence the statistical evidence that fish consumption lowers Alzheimer's incidence is quite robust so how could this be true the answer is that fish contains anti-inflammatory fatty acids because inflammation is a much more important risk factor the Mercury exposure is a comparatively minor contributor inflammation is known to be associated with degenerative diseases of many kinds further more information is known to be associated with many neurological diseases so we can only conclude that information is a bigger risk factor than Mercury exposure and clinical effort should have a primary focus on controlling inflammation there are several mechanisms of inflammation that may have a direct bearing on Alzheimer's disease one of the primary response is an inflammation is the induction of cytokines which are cell signaling factors that mobilize and coordinate the immune system towards potential infections and allergens one of the things that cytokines do is to activate other enzymes two of which are aromatase and Ido which is an abbreviation for indoleamine dioxygen A's aromatase and I do have survival value in fighting infections aromatase increases estrogens it does this by converting testosterone to estradiol and androstene died on to a strown the advantage of this is that estrogens turn off genetic transcription in protein synthesis which decreases any collateral DNA damage that might otherwise occur from the oxidants and free radicals that the immune system uses to fry infectious bugs the bad side is that estrogens inhibit energy systems that would otherwise maintain ATP synthesis and antioxidant recycling the decrease of testosterone and progesterone by Roma Tay's also decreases energy production the enzyme I do breaks down tryptophan which is an amino acid that some infections need in order to thrive but decreased tryptophan causes decreased serotonin and decrease melatonin which you need for happiness and well-being in addition low serotonin causes depression increased sensitivity to pain and impairment of Sleep Quality and the combination of poor sleep and low melatonin cause neuroendocrine dysregulation in addition to the alterations of the testosterone estradiol ratio to Progesterone estrogen ratio and androstene Dayan oestrone ratio the down regulation of energy Pathways inhibits to write a Genesis at its root this decreases the neuroprotective effects of pregnenolone and progesterone and sabotages the pro-energy effects of progesterone and testosterone let's look at this in more detail the steroid tree shows the metabolic Paths of steroids the root of the tree is cholesterol which is the ultimate source for all steroids the trunk of the tree is pregnenolone which is the point at which branching begins for neurological conditions the neuroprotective steroids are at the base of the tree with pregnenolone and progesterone being the strongest and DHEA being a very weak third the androgenic steroids are on the left with DHEA being quite mild and testosterone and dihydrotestosterone being quite potent these hormones play a significant role in upregulating energy Pathways along with progesterone the estrogenic hormones are at the top of the tree with estradiol and a strown being the strongest the flow of steroids into the estrogen section of the tree is regulated by the aromatase enzyme at these three points increase aromatase activity increases estrogen and influence which down-regulate energy Pathways and decreases estrogen precursors which would otherwise support the energy pathways and the neurotoxic hormone cortisol is on the right side cortisol tends to increase markedly to compensate for low metabolism the shift from a pro-energy neuroprotective steroid pattern with progesterone testosterone and pregnenolone to an anti-energy neurotoxic pattern with estrogen and cortisol is potentially catastrophic to the brain when the Mercury glutathione balance is weak the sources of inflammation Are Legion the most familiar are infections which span the range from the high-profile like viruses bacteria and fungi to the more obscure by toenail fungus and anaerobes in root canal teeth allergies are another category that deserves elaboration immediate hypersensitivities are obvious to everybody to both medical professionals that test them with skin injection challenges and two patients who experience rashes welts and boils within minutes to hours of exposure however delayed hypersensitivities are an entirely different kind of allergy they are mediated through IGA IGG and IGM antibodies and are not immediately obvious to the people who are exposed they are popularly called food allergies and their pathologies and their inflammatory influence has been denied by most medical allergist for many decades there adverse influences are greatly magnified by digestive weaknesses use of antacids use of H blocking anti indigestion drugs and buy leaky gut syndrome many common foods like wheat corn milk and yeast are among the highest risk for delayed hypersensitivities so our personal favorite foods which produce short-term feelings of well-being at the earliest stages of inflammation oxidative stress is a general inflammatory influence this can occur due to heavy metal exposure which poisons enzyme systems or from nutritional deficiencies which can undermine antioxidant systems also worth mentioning our chemical exposures like pesticides from Agriculture and aldehydes from particle board glues and Carpeting and from lifestyle factors like alcoholism it's just a cursory exploration of this topic the brain is only 3% of the body's Mass but consumes 20% of the body's energy this disproportionate energy use is required to power the microtubule transport system and the phosphorylation cycle these brain systems require the robust energy that can only be derived by aerobic energy processes they are also highly sensitive to Mercury toxicity which is otherwise controlled by binding to glutathione and by the energy driven recycling of glutathione glutathione is the critical process for preventing and reversing Alzheimer's disease if you want to go on to hear about at home testing options how to get in touch with me or supplemental slides dealing with dental risk factors Transcript
I put together the PowerPoint presentation that has been converted into this series of mini videos for YouTube altogether there are nine Parts this is part 1 because of the length of the opening animation and the 10 minute YouTube limit I cannot start with the usual set of introductory remarks but rather than abandon them they have been moved into the opening dialogue of subsequent videos so if you have questions about why am I telling you this story why isn't this information on Primetime TV News why is this presentation so technical please be patient will get to them in the ninth video contact information will be provided for how to get in touch with me how do I arrange for consulting services with scientific medical professionals who understand the themes of this presentation and where to find additional resources let's start with the take-home message you can prevent and reverse Alzheimer's disease this presentation will show you the central metabolic failure in the Alzheimer's disease process and how to go about fixing it it will also present the possible complicating factors that may be aggravating it but he will not tell you everything that you should or might do a particular case of Alzheimer's disease may have other complications at Play from a deficiency of B12 or B3 or toxicity from lead or trans fat or inflammatory activation from toenail fungus or food allergy to wheat this is not a strict recipe for Alzheimer's reversal you will have to figure out which parts of the program are the highest priorities for your particular case but one thing is clear the earlier you start the better the results this is because the metabolic malfunctions in the earliest stages of Alzheimer's disease are known to be largely reversible but the cell damage to neurons and dendrites or the outright cell death known as apoptosis that are believed to accumulate over time are mostly not reversible let me paint a picture for you of Alzheimer's disease step by step starting with a dashed line which is slanted to show that the Universe and our environment are not Level Playing Fields and that we need to strive to stay alive specifically here I want to convey redox potential redox is a fancy name for the balance between reduction the gaining of electrons and oxidation the losing of electrons reduction oxidation redox for short redox is important because our bodies need lots of electrons to be alive but are oxygen nitrogen atmosphere is very poor in electrons so we must struggle to get electrons if we lose that struggle we slide down the dash line into death the star of our movie is glutathione which is abbreviated gsh the G stands for glutathione and the sh stands for the self Hydro Group which is its active site glutathione is rich in electrons which are carried on the sofa Hydro group in her wisdom Mother Nature has provided us with lots of glutathione so that the redox balance always stays tip to the reduce side in opposition to the slant of the line which is tipped towards oxidation when some oxidative stress comes our way the glutathione offers up its electrons as a sacrifice so that other more important body structures are not damaged by having their precious electrons stolen bsh converts to us and we end up with gssg which is oxidized glutathione the oxidized glutathione has now done its job and is used up but it is not forgotten Mother Nature has also provided a way to give back the electronic glutathione to restore it to its reduce state this reduction of oxidized glutathione back into reduced glutathione is driven by the energy systems of the body this recycling of glutathione allows each glutathione a molecule used hundreds and thousands of times before it may become irreversibly damaged but glutathione also moonlights as a Mercury to talk safire by binding to Mercury which has the symbol HG glutathione convert mercury into a bound form gshg which has dramatically less toxicity this shifts the balance of the Mercury closer to the fulcrum point on the teeter-totter which keeps it from tipping the wrong way next to the Teeter Totter are the Alzheimer's disease enzyme systems that are sensitive to Mercury these enzymes have self Hydro groups in their active sites so glutathione must bind all the Mercury to prevent the Mercury from binding to the enzymes when the Energy System falters glutathione recycling becomes impaired this decreases the amount of glutathione and allows Mercury to escape finding free Mercury increases this tips the balance and knocks over the first Domino the enzyme creatine kinase which would otherwise provide the cell with emergency backup energy Reserves then the phosphorylation Domino Falls this phosphorylation cycle would otherwise regulate the long-term stability of brain metabolism and keep the brains microstructure adjusted properly continued Mercury influence then knocks over the microtubule Domino which would otherwise transport material down the long thin axons and dendrites of the brain and finally after extended weeks and months of ongoing Mercury mediated pathology beta amyloid plaques form which clogs the brain with garbage this is the state at which Alzheimer's disease is finally recognizable and it's full-blown medical context and where it might be identified by standard tests like brain-imaging or autopsy micrographs what is the strategy for reversal restore cellular energy mechanisms increase energy to recycle more glutathione find Toulouse Mercury decrease Unbound Mercury and tip the scale back to a reduce State then natural healing mechanisms can replace inhibited enzymes reactivate the phosphorylation cycle reassemble microtubules and digest beta-amyloid protein although energy restoration is likely to be the biggest influence there are many other adjunct therapies to assist with the process like reducing total body Mercury burden increasing the amount of glutathione that the body makes reducing secondary stresses to the glutathione system information for example or correcting nutrient deficiencies that impair metabolic efficiency |
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