Alzheimer's Reversal #8 of 9

Transcript

This presentation finally we get to the huge and vitally important topic of inflammation inflammation is the core of one of the oddest puzzles of Alzheimer's disease in a disease that is positively associated with Mercury as a risk factor why does the consumption of fish which contains elevated levels of mercury actually lower Alzheimer's disease incidence the statistical evidence that fish consumption lowers Alzheimer's incidence is quite robust so how could this be true the answer is that fish contains anti-inflammatory fatty acids because inflammation is a much more important risk factor the Mercury exposure is a comparatively minor contributor inflammation is known to be associated with degenerative diseases of many kinds further more information is known to be associated with many neurological diseases so we can only conclude that information is a bigger risk factor than Mercury exposure and clinical effort should have a primary focus on controlling inflammation there are several mechanisms of inflammation that may have a direct bearing on Alzheimer's disease one of the primary response is an inflammation is the induction of cytokines which are cell signaling factors that mobilize and coordinate the immune system towards potential infections and allergens one of the things that cytokines do is to activate other enzymes two of which are aromatase and Ido which is an abbreviation for indoleamine dioxygen A's aromatase and I do have survival value in fighting infections aromatase increases estrogens it does this by converting testosterone to estradiol and androstene died on to a strown the advantage of this is that estrogens turn off genetic transcription in protein synthesis which decreases any collateral DNA damage that might otherwise occur from the oxidants and free radicals that the immune system uses to fry infectious bugs the bad side is that estrogens inhibit energy systems that would otherwise maintain ATP synthesis and antioxidant recycling the decrease of testosterone and progesterone by Roma Tay's also decreases energy production the enzyme I do breaks down tryptophan which is an amino acid that some infections need in order to thrive but decreased tryptophan causes decreased serotonin and decrease melatonin which you need for happiness and well-being in addition low serotonin causes depression increased sensitivity to pain and impairment of Sleep Quality and the combination of poor sleep and low melatonin cause neuroendocrine dysregulation in addition to the alterations of the testosterone estradiol ratio to Progesterone estrogen ratio and androstene Dayan oestrone ratio the down regulation of energy Pathways inhibits to write a Genesis at its root this decreases the neuroprotective effects of pregnenolone and progesterone and sabotages the pro-energy effects of progesterone and testosterone let's look at this in more detail the steroid tree shows the metabolic Paths of steroids the root of the tree is cholesterol which is the ultimate source for all steroids the trunk of the tree is pregnenolone which is the point at which branching begins for neurological conditions the neuroprotective steroids are at the base of the tree with pregnenolone and progesterone being the strongest and DHEA being a very weak third the androgenic steroids are on the left with DHEA being quite mild and testosterone and dihydrotestosterone being quite potent these hormones play a significant role in upregulating energy Pathways along with progesterone the estrogenic hormones are at the top of the tree with estradiol and a strown being the strongest the flow of steroids into the estrogen section of the tree is regulated by the aromatase enzyme at these three points increase aromatase activity increases estrogen and influence which down-regulate energy Pathways and decreases estrogen precursors which would otherwise support the energy pathways and the neurotoxic hormone cortisol is on the right side cortisol tends to increase markedly to compensate for low metabolism the shift from a pro-energy neuroprotective steroid pattern with progesterone testosterone and pregnenolone to an anti-energy neurotoxic pattern with estrogen and cortisol is potentially catastrophic to the brain when the Mercury glutathione balance is weak the sources of inflammation Are Legion the most familiar are infections which span the range from the high-profile like viruses bacteria and fungi to the more obscure by toenail fungus and anaerobes in root canal teeth allergies are another category that deserves elaboration immediate hypersensitivities are obvious to everybody to both medical professionals that test them with skin injection challenges and two patients who experience rashes welts and boils within minutes to hours of exposure however delayed hypersensitivities are an entirely different kind of allergy they are mediated through IGA IGG and IGM antibodies and are not immediately obvious to the people who are exposed they are popularly called food allergies and their pathologies and their inflammatory influence has been denied by most medical allergist for many decades there adverse influences are greatly magnified by digestive weaknesses use of antacids use of H blocking anti indigestion drugs and buy leaky gut syndrome many common foods like wheat corn milk and yeast are among the highest risk for delayed hypersensitivities so our personal favorite foods which produce short-term feelings of well-being at the earliest stages of inflammation oxidative stress is a general inflammatory influence this can occur due to heavy metal exposure which poisons enzyme systems or from nutritional deficiencies which can undermine antioxidant systems also worth mentioning our chemical exposures like pesticides from Agriculture and aldehydes from particle board glues and Carpeting and from lifestyle factors like alcoholism it's just a cursory exploration of this topic the brain is only 3% of the body's Mass but consumes 20% of the body's energy this disproportionate energy use is required to power the microtubule transport system and the phosphorylation cycle these brain systems require the robust energy that can only be derived by aerobic energy processes they are also highly sensitive to Mercury toxicity which is otherwise controlled by binding to glutathione and by the energy driven recycling of glutathione glutathione is the critical process for preventing and reversing Alzheimer's disease if you want to go on to hear about at home testing options how to get in touch with me or supplemental slides dealing with dental risk factors