Alzheimer's Reversal #3 of 9

Transcript
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Here we will present a one-page map of the Alzheimer's process and the first domino in the Alzheimer's Cascade but before that give me a minute to develop one point given the popular belief that a diagnosis of Alzheimer's disease is tantamount to a death sentence a death of the self if not if the body the reversibility of Alzheimer's disease may be difficult to accept why isn't this Front Page News you might ask there are two answers to this question one flattering and one not first the researchers at the University of Kentucky and the University of Calgary who cracked the Alzheimer's code we're Dentistry scientists not Alzheimer's researchers and so the Breakthrough came through the backdoor furthermore their research implied a fundamental criticism of two of the core assumptions of the u.s. dental profession that mercury-containing Dental fillings were basically safe and it root canal procedures are basically safe second the new understanding of Alzheimer's disease favored generic therapies not high-profit drugs it did not support the billions of dollars already invested by drug companies in finding a disease management solution to the Alzheimer's problem but rather undermined it with non Prescription Solutions that can be bought at your local health food store Supermarket or neighborhood pharmacy this diagram is a flowchart for Alzheimer's disease it is provided for those of us who do better with pictures than with words please do not worry about not understanding at all and first glance or even after a once-through the presentation it has all the core elements and systems in one chart so it has to be complicated but we will talk about each section of the diagram and turn so that by the end of the presentation you should understand most of it to help Orient you the diagram is color coded with the energy system in the center and yellow like sunlight to indicate power or energy feeding it from above is the circulatory system in red the color of blood with glucose oxygen and fat dry Ketone fuels as the energy inputs delivered by Blood The Energy System output is ATP GTP and nadh where ATP and GTP are still in yellow and nadh is the most powerful reducing agent is icy blue which is a cold color to indicate antioxidant power so the cold antioxidants protect against the hot free radicals that are on automatic consequence of the energy production process the magenta to violet color tones indicate Alzheimer's Associated phenomena with the earlier stages being Vivid magenta and the latter stages being more muted Violet although most of the Alzheimer's elements are grouped on the right side they flow from the extreme left of the diagram via a magenta dashed line from where Mercury the brightest magenta is in a dynamic balance with the antioxidant glutathione glutathione is the principal antioxidant of the cell and is responsible for detoxifying Mercury both roles are fundamentally critical to health and especially critical to the function of the brain and it is the loss of glutathione dominance over Mercury that tips the balance and initiates Alzheimer's pathologies all of the remaining slides deal with some aspect of the general role of the glutathione system and the specific consequences of glutathione failure to known aspects of Alzheimer's disease we will start with Energy Systems in the center of the diagram and then Branch out to peripheral elements of the diagram a bit later mitochondria are the aerobic power plants of the cell the small inside area is magnified in the large illustration to show details of the membranes and intermembrane spaces the mitochondria is job is to produce reducing power nadh in blue and energy ATP in red mitochondria are small bean-shaped cellular organelles with a double membrane the inner membrane of which is convoluted or pleated like an accordion to maximize surface area the key energy production structures are proteins floating in the inner membrane labeled complex 1 through complex 5 these complexes form a chain which is cold blue at one end and hot red on the other end the blue and complex one accepts the fuel or reducing agent nadh also in blue and the red end complex for except the oxygen which is the oxidizing agent the power transfer system is from complex one complex 3 and complex for which pump protons or H+ across the inner membrane and complex five which converts the accumulated proton pressure call proton motive Force into ATP the key take-home concept is that nadh plays two critical roles in the energy systems first the production of ATP is completely dependent on nadh which pushes the power transfer system at the cold end of the chain to compliment oxygen pulling the power transfer system at the hot end of the chain second nadh is a source for reducing power to recycle antioxidants like glutathione and vitamin C the significance of both of these Concepts will be elaborated a bit later but first let's talk about the backup power system creatine kinase is a battery backup system for the cell it is a self Hydro enzyme meaning that it has an sh group at its active site just like glutathione does so it has the same affinity for mercury that glutathione does but there's thousands of times more glutathione around to protect the creatine kinase from Mercury inhibition creatine phosphate is the storage form for the backup energy creatine kinase converts ATP to creatine phosphate when ATP is plentiful which is shown by the blue arrows and it runs backwards to convert creatine phosphate back into ATP when ATP is scarce as shown by the white arrows this extends the cell's energy reserves from a couple of seconds too many seconds creatine kinase is known to be inhibited by Mercury and it is 95% inhibited and Alzheimer's disease this catastrophic failure of the energy backup system contributes to memory impairment cognitive dysfunction and a serious loss of physical stamina deficiencies of ATP adversely affect the activity of enzymes this has inhibiting effect on protein synthesis neurotransmitter synthesis steroid synthesis maintenance of electrical Potentials in neurons and a whole host of other health-related prophecies ATP shortages also decrease the availability of GTP and ATP cousin that assembles and maintains the tubulin infrastructure of brain neurons that facilitates material transport down neural axons and dendrites now let's move up from the yellow Energy Systems to the red circulatory system the heart and circulatory system are responsible for delivering oxygen glucose fats and Ketone fuels to the Deep tissues of the body and for removing the waste products of energy metabolism this system also includes the lungs which must adequately absorb oxygen from the air and Outkast carbon dioxide that results from energy metabolism